HIV-Gag (AA 450-497) Antikörper (AbBy Fluor® 680)

Produktnummer ABIN5004721

Der Kaninchen Polyklonal Anti--Antikörper wurde für IF (cc) und IF (p) validiert. Er ist geeignet, in Proben von Virus zu detektieren.

Kurzübersicht für HIV-Gag (AA 450-497) Antikörper (AbBy Fluor® 680) (ABIN5004721)

Target: HIV-Gag

Reaktivität: Virus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: AbBy Fluor® 680

Applikation: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails

Bindungsspezifität: AA 450-497

Kreuzreaktivität: Virus

Kreuzreaktivität (Details): HIV

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from HIV P6-Gag

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Antigendetails

Target: HIV-Gag

Andere Bezeichnung: HIV Gag Polyprotein

Substanzklasse: Viral Protein

Hintergrund:

Synonyms: HIV1 Pr55Gag, Human immunodeficiency virus 1, Gag protein p6, MA antibody Matrix protein, Matrix protein p17, Pr55, Pr55Gag.

Background: Human immunodeficiency virus (HIV) is a retrovirus that can lead to a condition in which the immune system begins to fail, leading to opportunistic infections. HIV primarily infects vital cells in the human immune system such as helper T cells(specifically CD4+ T cells), macrophages and dendritic cells. HIV infection leads to low levels of CD4+ T cells through three main mechanisms: firstly, direct viral killing of infected cells, secondly, increased rates of apoptosis in infected cells, and thirdly, killing of infected CD4+ T cells by CD8 cytotoxic lymphocytes that recognize infected cells. When CD4+ T cell numbers decline below a critical level, cell-mediated immunity is lost, and the body becomes progressively more susceptible to opportunistic infections. HIV was classified as a member of the genus Lentivirus, part of the family of Retroviridae. Lentiviruses have many common morphologies and biological properties. Many species are infected by lentiviruses, which are characteristically responsible for long-duration illnesses with a long incubation period. Lentiviruses are transmitted as single-stranded, positive-sense, enveloped RNA viruses. Upon entry of the target cell, the viral RNA genome is converted to double-stranded DNA by a virally encoded reverse transcriptase that is present in the virus particle. This viral DNA is then integrated into the cellular DNA by a virally encoded integrase so that the genome can be transcribed. Once the virus has infected the cell, two pathways are possible: either the virus becomes latent and the infected cell continues to function, or the virus becomes active and replicates, and a large number of virus particles are liberated that can then infect other cells.